4-(4-Methylbenzoyl)piperidine hydrochloride → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-ylmethyl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone
반응식
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.Cl.[NH:19]1[CH2:24][CH2:23][CH:22]([C:25]([C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=2)=[O:26])[CH2:21][CH2:20]1>>[O:17]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:12]([N:19]2[CH2:24][CH2:23][CH:22]([C:25](=[O:26])[C:27]3[CH:28]=[CH:29][C:30]([CH3:33])=[CH:31][CH:32]=3)[CH2:21][CH2:20]2)=[O:14])=[CH:15][CH:16]=1참가 물질
3
실험 절차
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)benzoic acid (268 mg) described in Preparation Example 18 and (piperidin-4-yl)(p-tolyl)methanone hydrochloride (252 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (235 mg) was obtained.
출처 및 근거
- ORD 기록
- ord-e414cc5eb83840828ad2442df063301e