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Ethyl Acetate → [4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone hydrobromide

HRID 2411476
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인쇄 미리보기

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HRID 2411476 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][CH2:25][S:24]3(=[O:29])=[O:28])=[CH:19][C:18]=2[S:30]([CH3:33])(=[O:32])=[O:31])=[O:16])[CH2:11][CH2:10]1.[BrH:34].C(O)(=O)C.C(OCC)(=O)C>CC(C)=O>[BrH:34].[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][CH2:25][S:24]3(=[O:28])=[O:29])=[CH:19][C:18]=2[S:30]([CH3:33])(=[O:32])=[O:31])=[O:16])[CH2:13][CH2:14]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 71252359[4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone

생성물 1

HCID 86676777[4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone hydrobromide

시약·촉매·용매 1

HCID 180
Acetone
용매

실험 절차

[4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone (500 mg) described in Example 11 was dissolved in acetone (75 mL), hydrogen bromide/acetic acid solution (about 30%-containing, 0.3 mL) was added, and the mixture was stirred at room temperature. To the reaction mixture was added ethyl acetate, and the precipitate was collected by filtration to give the title compound (283 mg).

후처리

  1. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-04a3a5c7542e49dd8a11a3f852ec55a7
출처 데이터셋
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08816079B2

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