1,3-Propanesultam → HCID 71252896, 화합물

HRID 2411516

반응식

HRID 2411516 반응식
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[S:24]1(=[O:30])(=[O:29])[CH2:28][CH2:27][CH2:26][NH:25]1>>[O:29]=[S:24]1(=[O:30])[CH2:28][CH2:27][CH2:26][N:25]1[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 6421571,3-PropanesultamHCID 58484591(6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone

생성물 1

HCID 71252896HCID 71252896, 화합물수율 24.1%

실험 절차

Using (6-bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone (548 mg) described in Preparation Example 193 and isothiazolidine 1,1-dioxide (177 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (146 mg) was obtained.

출처 및 근거

ORD 기록
ord-f66682ffb894410facd9ebf5d49a349b
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

연결된 노트

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