HCID 67381204, 화합물 → [4-(2,4-Dicyclopropylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

HRID 2411607노트

반응식

HRID 2411607 반응식
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][N:8]=1.[CH:19]1([C:22]2[CH:27]=[C:26]([CH:28]3[CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:27]=[C:26]([CH:28]3[CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N:31]2[CH2:32][CH2:33][N:34]([C:11]([C:10]3[CH:9]=[N:8][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:17][CH:16]=3)=[O:13])[CH2:35][CH2:36]2)[CH2:20][CH2:21]1

참가 물질

3

반응물 2

HCID 67381204HCID 67381204, 화합물HCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

생성물 1

HCID 71252667[4-(2,4-Dicyclopropylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone수율 72.4%

실험 절차

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(2,4-dicyclopropylphenyl)piperazine (296 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Example 109, the title compound (375 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Example 109

출처 및 근거

ORD 기록
ord-2f2377f3e4c54b60ba47d1d0645a969b
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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