Methyl p-toluenesulfonate → (S)-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-5-methoxymethylpyrrolidin-2-one
반응식
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:36])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][OH:30])[CH2:27][CH2:26][C:25]5=[O:31])=[CH:20][C:19]=4[S:32]([CH3:35])(=[O:34])=[O:33])=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.S(C1C=CC(C)=CC=1)(O[CH3:41])(=O)=O>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:36])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][O:30][CH3:41])[CH2:27][CH2:26][C:25]5=[O:31])=[CH:20][C:19]=4[S:32]([CH3:35])(=[O:33])=[O:34])=[O:17])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1참가 물질
3
반응물 2
생성물 1
실험 절차
Using (S)-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-5-hydroxymethylpyrrolidin-2-one (240 mg) described in Example 298 and methyl tosylate (71 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (28 mg) was obtained.