4-((2-Oxopyrrolidin-1-yl)methyl)benzoic acid → HCID 71251923, 화합물

HRID 2411728노트

반응식

HRID 2411728 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:27][CH2:28][N:29]([C:12]([C:11]4[CH:10]=[CH:9][C:8]([CH2:7][N:3]5[CH2:4][CH2:5][CH2:6][C:2]5=[O:1])=[CH:16][CH:15]=4)=[O:14])[CH2:30][CH2:31]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 49622004-((2-Oxopyrrolidin-1-yl)methyl)benzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

생성물 1

HCID 71251923HCID 71251923, 화합물수율 36.1%

실험 절차

Using 4-(2-oxopyrrolidin-1-ylmethyl)benzoic acid (132 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (156 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (91 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

출처 및 근거

ORD 기록
ord-c3b2397d86e049a7a308847c7023e841
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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