1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → (1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl ester

HRID 2411832노트

반응식

HRID 2411832 반응식
[CH2:1]([O:3][C:4]([NH:6][C:7]([C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=1)([CH3:9])[CH3:8])=[O:5])[CH3:2].[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)CC1>>[CH2:1]([O:3][C:4](=[O:5])[NH:6][C:7]([C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:26]3[C:25]([CH3:35])=[CH:24][C:23]([CH3:20])=[CH:28][N:27]=3)[CH2:30][CH2:31]2)=[O:16])=[CH:18][CH:19]=1)([CH3:8])[CH3:9])[CH3:2]

참가 물질

3

반응물 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252297Methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate

생성물 1

HCID 71252363(1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl ester수율 84.4%

실험 절차

Using methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate (174 mg) described in Preparation Example 70 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (157 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (235 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

출처 및 근거

ORD 기록
ord-3dc63005760b4cde815bd02ad4a62f0d
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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