(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → 1-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4,4-dimethylimidazolidin-2-one

HRID 2411862노트

반응식

HRID 2411862 반응식
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.C([N:32]1[C:36]([CH3:38])([CH3:37])[CH2:35][NH:34][C:33]1=[O:39])(=O)C1C=CC=CC=1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:34]4[CH2:35][C:36]([CH3:38])([CH3:37])[NH:32][C:33]4=[O:39])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

참가 물질

3

반응물 2

HCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 712521131-Benzoyl-5,5-dimethylimidazolidin-2-one

생성물 1

HCID 712520741-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4,4-dimethylimidazolidin-2-one수율 36.7%

실험 절차

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 127 and 1-benzoyl-5,5-dimethylimidazolidin-2-one (105 mg) described in Preparation Example 58 and by the reaction and treatment in the same manner as in Example 509 to give the title compound (60 mg) produced by debenzoylation that simultaneously proceeded during the reaction.

후처리

  1. customdescribed in Preparation Example 58 and by the reaction and treatment in the same manner as in Example 509

출처 및 근거

ORD 기록
ord-9347aad7969f48e7a8b2d86ef9ee849e
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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