3,5,5-Trimethylimidazolidine-2,4-dione → 3,5,5-Trimethyl-1-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}imidazolidine-2,4-dione

HRID 2411939노트

반응식

HRID 2411939 반응식
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:25][N:26]1[C:30](=[O:31])[C:29]([CH3:33])([CH3:32])[NH:28][C:27]1=[O:34]>>[CH3:25][N:26]1[C:30](=[O:31])[C:29]([CH3:33])([CH3:32])[N:28]([C:2]2[CH:3]=[CH:4][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[CH:6][N:7]=2)[C:27]1=[O:34]

참가 물질

3

반응물 2

HCID 2375603,5,5-Trimethylimidazolidine-2,4-dioneHCID 58484612(6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

생성물 1

HCID 712523863,5,5-Trimethyl-1-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}imidazolidine-2,4-dione수율 63.1%

실험 절차

Using (6-bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (156 mg) described in Preparation Example 205 and 3,5,5-trimethylimidazolidine-2,4-dione (63 mg) described in Preparation Example 218 and by the reaction and treatment in the same manner as in Example 536, the title compound (114 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 218 and by the reaction and treatment in the same manner as in Example 536

출처 및 근거

ORD 기록
ord-d55e89af8999476e9085e93cc0b392fd
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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