N-Acetylimidazolidinone → HCID 71252544, 화합물

반응식

Br[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH:23]4[CH2:25][CH2:24]4)=[CH:21][C:20]([CH:26]4[CH2:28][CH2:27]4)=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[C:29]([N:32]1[CH2:36][CH2:35][NH:34][C:33]1=[O:37])(=[O:31])[CH3:30]>>[C:29]([N:32]1[CH2:36][CH2:35][N:34]([C:2]2[CH:3]=[CH:4][C:5]([C:9]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[C:22]([CH:23]5[CH2:25][CH2:24]5)=[CH:21][C:20]([CH:26]5[CH2:28][CH2:27]5)=[CH:19][N:18]=4)[CH2:13][CH2:12]3)=[O:10])=[C:6]([CH3:8])[N:7]=2)[C:33]1=[O:37])(=[O:31])[CH3:30]

참가 물질

반응물 2

HCID 79350N-Acetylimidazolidinone

HCID 86676773HCID 86676773, 화합물

생성물 1

HCID 71252544HCID 71252544, 화합물수율 87.1%

실험 절차

Using (6-bromo-2-methylpyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (221 mg) described in Preparation Example 251 and 1-acetylimidazolidin-2-one (77 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (213 mg) was obtained.

출처 및 근거

ORD 기록: ord-c7f7ab7bf3fc4fbda548099f69a28cdc
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

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