Morpholine → HCID 71252539, 화합물

HRID 2412110노트

반응식

C(OC([N:8]([C:40](OC(C)(C)C)=O)[C:9](=[O:39])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH2:37][CH3:38])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.N1C[CH2:51][O:50][CH2:49][CH2:48]1>>[CH2:37]([C:33]1[CH:34]=[C:35]([CH3:36])[C:30]([N:27]2[CH2:28][CH2:29][N:24]([C:22]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:20][CH2:19][CH2:18][C:17]4=[O:21])=[CH:15][C:10]=3[C:9]([N:8]3[CH2:40][CH2:51][O:50][CH2:49][CH2:48]3)=[O:39])=[O:23])[CH2:25][CH2:26]2)=[N:31][CH:32]=1)[CH3:38]

참가 물질

반응물 2

HCID 8083Morpholine

HCID 71252122HCID 71252122, 화합물

생성물 1

HCID 71252539HCID 71252539, 화합물

실험 절차

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (70 mg) described in Example 809 and morpholine (41 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (19 mg) was obtained.

출처 및 근거

ORD 기록: ord-b74fe8172eb740e38a1358de36c00447
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

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