Benzene, (triethoxymethyl)- → 4-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 2412920

반응식

HRID 2412920 반응식
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.CCO[C:17](OCC)(OCC)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Cl:1][C:2]1[C:11]2[N:10]([C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

참가 물질

4

반응물 2

HCID 74268Benzene, (triethoxymethyl)-HCID 36588202-Chloro-3-hydrazinoquinoxaline

생성물 1

HCID 8992904-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Chloro-3-hydrazinoquinoxaline (2.2 g., 0.011) mole) was mixed with 6 ml. of triethyl orthobenzoate and heated at 100° C. for 30 minutes. After cooling the orange mixture to room temperature, ethanol was added. Filtration of the resultant precipitate afforded 2.1 g. of crude product which was further purified by means of trituration with warm methanol, followed by filtration and air drying to ultimately yield 1.58 g. (51%) of pure 4-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline as an orange solid.

후처리

  1. filtrationFiltration of the resultant precipitate
  2. customafforded 2.1 g
  3. customof crude product which was further purified by means of trituration with warm methanol
  4. filtrationfollowed by filtration and air
  5. customdrying to ultimately yield 1.58 g

출처 및 근거

ORD 기록
ord-30202746205149a58a4efaeb0546e455
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04495187

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