4-(Aminosulfonyl)-5-chlorophthalimide → 1-Pentanol
반응식
Cl[C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[NH:8][C:6](=[O:7])[C:5]2=[CH:11][C:12]=1S(=O)(=O)N.NC1CCN(CC2C=CC=C(C(F)(F)F)C=2)CC1>>[CH2:6]([OH:7])[CH2:5][CH2:4][CH2:3][CH3:2].[O:7]=[C:6]1[C:5]2[C:4](=[CH:3][CH:2]=[CH:12][CH:11]=2)[C:9](=[O:10])[NH:8]1참가 물질
4
실험 절차
Reaction of 4-chloro-5-sulfamoylphthalimide (10.1 g., 0.0386 mole) and 4-amino-1-(3-trifluoromethylbenzyl)piperidine (10.0 g., 0.0386 mole) in 200 ml. of n-pentanol according to the procedure of Example 1(a) afforded the crude 1,3-dioxoisoindole product purified by chromatography to yield 8.1 g. (42% yield) of 6-chloro-2,3-dihydro-1,3-dioxo-2-[1-[[3-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]-1H-isoindole-5-sulfonamide. The NMR spectral data was consistent for the compound used without further purification below.
출처 및 근거
- ORD 기록
- ord-89c50013a4d74408a6bae3ee3d6af5fe
- 출처 데이터셋
- uspto-grants-1985_01
- 특허 번호
- US04495194
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