t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide → N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

HRID 2412961노트

반응식

HRID 2412961 반응식
C(OC([NH:8][C@H:9]([C:17]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:29].O1CCOCC1>O1CCOCC1>[ClH:29].[CH3:28][O:27][C:25](=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][NH:19][C:17](=[O:18])[C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH2:8]

참가 물질

4

반응물 2

HCID 12799279t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamideHCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 70402980N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of the title compound of Example 2 (43.1 g, 0.11 mole) in 100 ml of dioxane was added 100 ml of 6M hydrogen chloride/dioxane. After about 30 min. the solution was concentrated in vacuo to dryness and the residue triturated thoroughly with diethyl ether. The solid was collected and washed well with diethyl ether, giving 34.7 g of the title compound, which was used in subsequent reactions without further purification.

후처리

  1. concentrationAfter about 30 min. the solution was concentrated in vacuo to dryness
  2. customthe residue triturated thoroughly with diethyl ether
  3. customThe solid was collected
  4. washwashed well with diethyl ether

출처 및 근거

ORD 기록
ord-31f71a3ce384455e896ab566c21c56de
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04495178

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