t-butoxycarbonyl-D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide → D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride hemihydrate

HRID 2412964

반응식

HRID 2412964 반응식
C([O:5]C([NH:8][C@@H:9]([C:14]([NH:16][CH2:17][C:18]([NH:20][C@H:21]([C:29]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37]([O:39][CH3:40])=[O:38])=[O:30])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=O)(C)(C)C.[ClH:41].O1CCOCC1>O1CCOCC1>[OH2:5].[ClH:41].[NH2:8][C@@H:9]([C:14]([NH:16][CH2:17][C:18]([NH:20][C@H:21]([C:29]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37]([O:39][CH3:40])=[O:38])=[O:30])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])=[O:15])[CH2:10][CH2:11][S:12][CH3:13].[NH2:8][C@@H:9]([C:14]([NH:16][CH2:17][C:18]([NH:20][C@H:21]([C:29]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37](=[O:38])[O:39][CH3:40])=[O:30])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])=[O:15])[CH2:10][CH2:11][S:12][CH3:13].[ClH:41]

참가 물질

4

반응물 2

HCID 13385843t-butoxycarbonyl-D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamideHCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 131714086D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride hemihydrate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The title compound of Example 10 (12.0 g) was dissolved in 50 ml of dioxane to which was added 50 ml of 6M hydrogen chloride/dioxane. After about one hour, the volatiles were removed in vacuo and the residue triturated thoroughly with diethyl ether. The title compound (10.9 g) was collected as an analytically pure hydrochloride hemihydrate.

후처리

  1. customthe volatiles were removed in vacuo
  2. customthe residue triturated thoroughly with diethyl ether
  3. customThe title compound (10.9 g) was collected as an analytically pure hydrochloride hemihydrate

출처 및 근거

ORD 기록
ord-bf8a556c59714159bd146c7edc5367f4
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04495178

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