Cyanogen Bromide → HCID 13392479, 화합물

HRID 2413111노트

반응식

HRID 2413111 반응식
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH3:13])[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[N:14]#CBr>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([C:13]#[N:14])[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 10476Cyanogen BromideHCID 123981Benalfocin

생성물 1

HCID 13392479HCID 13392479, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A stirred solution of 1.2 g. of 6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine in 30 ml. of toluene was treated at 50° by dropwise addition with a solution of 0.7 g. cyanogen bromide in 25 ml. of toluene. Following the addition, the mixture was stirred and heated at 50° for one hour. A stream of nitrogen was passed over the surface of the solution during the reaction. The mixture was cooled, filtered and the filtrate concentrated in vacuo to yield 6-chloro-3-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine melting at 81°-82° from hexane-ether solution.

후처리

  1. additionthe addition
  2. temperatureheated at 50° for one hour
  3. customA stream of nitrogen was passed over the surface of the solution during the reaction
  4. temperatureThe mixture was cooled
  5. filtrationfiltered
  6. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-a4c454f5a33a4e32af9e5bf54f8064ad
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04496558

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