(Chloromethyl)(4-chlorophenyl)dimethylsilane → (4-Chlorophenyl)dimethyl(1H-imidazol-1-ylmethyl)silane

HRID 2413307노트

반응식

HRID 2413307 반응식
Cl[CH2:2][Si:3]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)([CH3:5])[CH3:4].[Na].[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>CN(C)C=O.O>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([Si:3]([CH3:5])([CH3:4])[CH2:2][N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 2733089(Chloromethyl)(4-chlorophenyl)dimethylsilaneHCID 57373095Imidazole sodium

생성물 1

HCID 20430362(4-Chlorophenyl)dimethyl(1H-imidazol-1-ylmethyl)silane수율 81%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2.2 g (0.010 mol) of chloromethyl(4-chlorophenyl)dimethylsilane and 1.1 g (0.012 mol) of imidazole sodium salt in 5 ml of dimethylformamide was stirred at 80°-90° for 2 hours, cooled, diluted with water, and extracted with ether. The ether solution was washed with water and brine, dried over magnesium sulfate, and evaporated to leave 2.0 g (81%) of the title compound as a yellow liquid: nD20 1.5472; ir (neat) 1560, 1495, 1480, 1375, 1250, 1105, 1080, 905, 830, 810, 740 cm-1 ; nmr (CDCl3) 0.3 (6H, s), 3.6 (2H, s), 6.6 (1H, broad s), 6.9 (1H, broad s), 7.1 (1H, broad s), 7.3 (4H, s).

후처리

  1. temperaturecooled
  2. extractionextracted with ether
  3. washThe ether solution was washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-7f7f78be48114def9b364ce1bab25c3c
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04496551

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