1,4-Dioxane → 1-(4-Chlorobenzoyl)piperazine

HRID 241332

반응식

HRID 241332 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.O1CCOCC1>C(Cl)Cl>[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[O:22])=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 312751,4-DioxaneHCID 49814251tert-Butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate

생성물 1

HCID 41014841-(4-Chlorobenzoyl)piperazine수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-(4-Chloro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (26 g) was dissolved in CH2Cl2 (350 mL). 4M HCL/Dioxane (150 mL) was added. The mixture was stirred at RT for 4 h. White precipitate was formed. The mixture was concentrated. The white solid was washed with Et2O. After the white solid was treated with 1N NaOH (200 mL) and extracted with Ethyl acetate (3×100 mL), the combined organic phase was dried over Na2SO4 and concentrated to give 17.79 g of desired product (99% yield). 1H-NMR (for HCl salt) (300 MHz, MeOD): δ 2.80-2.90 (m, 4H), 3.20-3.80 (m, 4H), 7.29-7.36 (m, 4H).

후처리

  1. customWhite precipitate was formed
  2. concentrationThe mixture was concentrated
  3. washThe white solid was washed with Et2O
  4. additionAfter the white solid was treated with 1N NaOH (200 mL)
  5. extractionextracted with Ethyl acetate (3×100 mL)
  6. dry with materialthe combined organic phase was dried over Na2SO4
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-97d7bd9150eb4f0f87feb48ae598b1c9
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648197B2

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