Triethylamine → N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

HRID 24135

반응식

HRID 24135 반응식
[CH3:1][C:2]([CH3:7])=[CH:3][C:4](Cl)=[O:5].[Br:8][C:9]1[CH:16]=[CH:15][C:12]([NH:13][CH3:14])=[CH:11][CH:10]=1.C(N(CC)CC)C>ClCCl>[Br:8][C:9]1[CH:16]=[CH:15][C:12]([N:13]([CH3:14])[C:4](=[O:5])[CH:3]=[C:2]([CH3:7])[CH3:1])=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1023943-Methyl-2-butenoyl chlorideHCID 2757052Benzenamine, 4-bromo-N-methyl-

생성물 1

HCID 22568913N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,3-Dimethylacryloyl chloride (3 mL, 27 mmol) was added to a solution of 4-bromo-N-methyl-aniline (4.55 g, 25 mmol) in 150 mL of dichloromethane followed after 5 minutes by triethyl amine (5 mL, 33 mmol). After 2.5 h at ambient temperature, the reaction mixture was washed with water and the organic phase was dried over anhydrous sodium sulfate and evaporated in vacuo to afford the title product as a brown oil in quantitative yield.

후처리

  1. washthe reaction mixture was washed with water
  2. dry with materialthe organic phase was dried over anhydrous sodium sulfate
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-90623539d9304fb8841d096e490d9518
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855512B2

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