Adenine → HCID 13536441, 화합물

HRID 2413514노트

반응식

HRID 2413514 반응식
[S:1]1[CH:5]=[CH:4][C:3]([C:6](Cl)=[O:7])=[CH:2]1.[N:9]1[C:17]([NH2:18])=[C:16]2[C:12]([N:13]=[CH:14][NH:15]2)=[N:11][CH:10]=1>N1C=CC=CC=1>[CH:2]1[S:1][CH:5]=[CH:4][C:3]=1[C:6]([NH:18][C:17]1[N:9]=[CH:10][N:11]=[C:12]2[C:16]=1[NH:15][CH:14]=[N:13]2)=[O:7]

참가 물질

4

반응물 2

HCID 190AdenineHCID 27763773-Thenoyl chloride

생성물 1

HCID 13536441HCID 13536441, 화합물수율 60%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

62.6 g (0.439 mole) of thiophene-3-carbonyl chloride are added to a suspension of 19.7 g (0.146 mole) of adenine in 100 ml of dry pyridine. The mixture is refluxed for 10 hours, the pyridine is distilled off, the residue is taken up in chloroform, the solution is washed with dilute sodium bicarbonate solution and dried over sodium sulfate, and the solvent is then stripped off in a rotary evaporator. The solid residue is stirred repeatedly with cyclohexane and then recrystallized from ethanol and dried at about 40° C. under reduced pressure. 6-(3-Thenoylamino)-purine is obtained in a yield of 60%.

후처리

  1. temperatureThe mixture is refluxed for 10 hours
  2. distillationthe pyridine is distilled off
  3. washthe solution is washed with dilute sodium bicarbonate solution
  4. dry with materialdried over sodium sulfate
  5. customthe solvent is then stripped off in a rotary evaporator
  6. customrecrystallized from ethanol
  7. customdried at about 40° C. under reduced pressure

출처 및 근거

ORD 기록
ord-aec47a022e1740a7b713de7f63dd8bc5
출처 데이터셋
uspto-grants-1988_01
특허 번호
US04718936

반응 노트

불러오는 중…