Methyl 3-(4-acetyl-2-methylphenyl)acrylate → Methyl 3-[2-methyl-4-[3-[3-propyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]phenyl]acrylate
반응식
[CH2:1]([C:4]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:7]=2[S:6][C:5]=1[CH:17]=O)[CH2:2][CH3:3].[C:19]([C:22]1[CH:27]=[CH:26][C:25]([CH:28]=[CH:29][C:30]([O:32][CH3:33])=[O:31])=[C:24]([CH3:34])[CH:23]=1)(=[O:21])[CH3:20]>>[CH3:34][C:24]1[CH:23]=[C:22]([C:19](=[O:21])[CH:20]=[CH:17][C:5]2[S:6][C:7]3[CH:12]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:9][C:8]=3[C:4]=2[CH2:1][CH2:2][CH3:3])[CH:27]=[CH:26][C:25]=1[CH:28]=[CH:29][C:30]([O:32][CH3:33])=[O:31]참가 물질
3
실험 절차
The titled compound was prepared from the above-mentioned 3-propyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehyde (112 mg, 0.411 mmol) and methyl 3-(4-acetyl-2-methylphenyl)acrylate (90 mg, 0.41 mmol) in a procedure similar to that of Example 7 (1) as a yellow crystal (107 mg, yield 55%).
출처 및 근거
- ORD 기록
- ord-dec5b01e56084155910184cb807af82c
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08648208B2
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