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N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline benzylester → N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline

HRID 2413731
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HRID 2413731 반응식
C([O:8][C:9](=[O:34])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:33])[C@@H:16]1[CH2:20][CH2:19][CH2:18][N:17]1[C:21](=[O:32])[C@H:22]([CH3:31])[NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])C1C=CC=CC=1.[H][H]>CO.[C].[Pd]>[C:27]([O:26][C:24]([NH:23][C@H:22]([C:21]([N:17]1[CH2:18][CH2:19][CH2:20][C@H:16]1[C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([OH:34])=[O:8])=[O:33])=[O:32])[CH3:31])=[O:25])([CH3:28])([CH3:29])[CH3:30]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 13389836N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline benzylesterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22827655N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline수율 99.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline benzylester (5.0 g, 10.6 m mole) was dissolved in methanol (100 ml) and hydrogen gas was passed through the solution in the presence of the palladium carbon as a catalyst for 3 hours. The catalyst was removed by filtration and the solvent was distilled off under reduced pressure. Thus obtained residue was dissolved in water and the solution was freeze-dried to give N-t-butyloxycarbonyl-L-alanyl-L-prolyl-L-proline (4.04 g).

후처리

  1. customThe catalyst was removed by filtration
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThus obtained residue was dissolved in water
  4. customthe solution was freeze-dried

출처 및 근거

ORD 기록
ord-5f834158ad0144d7b17427348fa3791d
출처 데이터셋
uspto-grants-1988_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04719200

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