Ethanol → 2-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone

HRID 2413739

반응식

HRID 2413739 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10](=[S:13])[NH:11][NH2:12])[CH2:3][CH2:2]1.[C:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)(=O)[CH3:15].C(O)C>C(O)(=O)C>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][C:10](=[S:13])[NH:11][N:12]=[C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[CH3:15])[CH2:5][CH2:6]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 142862-AcetylpyridineHCID 7362093-Amino-1-(2-(morpholin-4-yl)ethyl)thiourea

생성물 1

HCID 544028592-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 6.00 g (0.0294 mole) of 4-(2-morpholinoethyl)thiosemicarbazide, 3.91 g (0.0323 mole) of 2-acetylpyridine, 20 mL of 95% ethanol, and 0.4 mL of glacial acetic acid was heated under reflux for 1.25 hours. The mixture then stood overnight at room temperature. Colourless crystals were collected and recrystallised from 40 mL of 95% ethanol; yield 7.81 g (86%) of pale yellow crystals of 2-acetylpyridine 4-(2-morpholinoethyl)thioseicarbazone, mp 167.5°-169° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 1.25 hours
  3. customColourless crystals were collected
  4. customrecrystallised from 40 mL of 95% ethanol

출처 및 근거

ORD 기록
ord-a7071a5459f34bbc99fc2494dadebae9
출처 데이터셋
uspto-grants-1988_01
특허 번호
US04719221

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