Veratrole → N-[2-[bis(1-methylethyl)amino]ethyl]-3,4-dimethoxy-N-(1-methylethyl)-benzenesulfonamide

HRID 2413999노트

반응식

HRID 2413999 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:11](Cl)(=[O:13])=[O:12])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C1(OC)C(=CC=CC=1)OC.ClS(O)(=O)=O.[CH:30]([N:33]([CH:40]([CH3:42])[CH3:41])[CH2:34][CH2:35][NH:36][CH:37]([CH3:39])[CH3:38])([CH3:32])[CH3:31]>>[CH3:42][CH:40]([N:33]([CH:30]([CH3:32])[CH3:31])[CH2:34][CH2:35][N:36]([CH:37]([CH3:39])[CH3:38])[S:11]([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:13])=[O:12])[CH3:41]

참가 물질

5

반응물 4

HCID 7043VeratroleHCID 24638Chlorosulfonic acidHCID 66797N,N,N'-TriisopropylethylenediamineHCID 27341833,4-Dimethoxybenzenesulfonyl chloride

생성물 1

HCID 14096741N-[2-[bis(1-methylethyl)amino]ethyl]-3,4-dimethoxy-N-(1-methylethyl)-benzenesulfonamide

실험 절차

3,4-Dimethoxybenzene sulfonyl chloride, prepared from veratrole and chlorosulfonic acid was reacted with N,N,N'-triisopropyl ethylene diamine following the procedure of Example 1. The reaction was worked up and the crude product chromatographed on alumina with ethyl acetate. The pure product was obtained, m.r. 69°-71° C.

후처리

  1. customthe crude product chromatographed on alumina with ethyl acetate
  2. customThe pure product was obtained
  3. custom69°-71° C.

출처 및 근거

ORD 기록
ord-4187c3dcec7a4b8b91d5168270a89606
출처 데이터셋
uspto-grants-1988_01
특허 번호
US04720580

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