2-Chloroethanol → 1-(2-Hydroxy-ethyl)-piperidine-4-carboxylic acid amide
반응식
Cl[CH2:2][CH2:3][OH:4].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].[C:13]([CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)(=[O:15])[NH2:14]>C(O)C>[OH:4][CH2:3][CH2:2][N:19]1[CH2:20][CH2:21][CH:16]([C:13](=[O:15])[NH2:14])[CH2:17][CH2:18]1참가 물질
6
실험 절차
2-Chloroethanol (23.9 ml), potassium carbonate (82.0 g) and sodium iodide (4.5 g) were added to an ethanol solution (500 ml) of 4-carbamoylpiperidine (35 g), followed by refluxing for 20 hours. After allowing the reaction mixture to cool down to room temperature, it was filtered through Celite (trade mark). The filtrate was concentrated under reduced pressure. After washing the residue, it was dried to obtain 46.6 g of the desired product.
후처리
- temperatureby refluxing for 20 hours
- filtrationit was filtered through Celite (trade mark)
- concentrationThe filtrate was concentrated under reduced pressure
- washAfter washing the residue, it
- customwas dried
출처 및 근거
- ORD 기록
- ord-e56d6e7c8f5f4578b3f97d929bf05aa7
- 출처 데이터셋
- uspto-grants-1988_01
- 특허 번호
- US04721788
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