Sodium Azide → 4-Chloro-3-cyanobenzyl azide
반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][C:3]=1[C:10]#[N:11].[N-:12]=[N+:13]=[N-:14].[Na+]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:12]=[N+:13]=[N-:14])=[CH:4][C:3]=1[C:10]#[N:11]참가 물질
4
실험 절차
A stirred mixture of 4-chloro-3-cyanobenzyl bromide (3.0 g, 13 mmol) and sodium azide (1.26 g, 19.4 mmol) was refluxed 5 hours in absolute ethanol (30 mL). The mixture was kept 18 hours at ambient temperature, filtered, and the filtrate was evaporated under vacuum. The residue was triturated with diethyl ether, filtered, and evaporated to provide 2.45 g (98%) liquid 4-chloro-3-cyanobenzyl azide; I.R. (neat): 2240, 2100 cm1.
후처리
- filtrationfiltered
- customthe filtrate was evaporated under vacuum
- customThe residue was triturated with diethyl ether
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-3c891f33b847442097777ea209d70180
- 출처 데이터셋
- uspto-grants-1988_01
- 특허 번호
- US04721791
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