6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

HRID 2414330노트

반응식

HRID 2414330 반응식
[ClH:1].[CH3:2][CH:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:5](=[O:19])[O:4]1.Cl[C:21]1[N:26]=[CH:25][C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:22]=1>>[Cl:1][C:22]1[CH:23]=[C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])[CH:25]=[N:26][C:21]=1[N:16]1[CH2:17][CH2:18][CH:13]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[CH:3]([CH3:2])[O:4][C:5]2=[O:19])[CH2:14][CH2:15]1

참가 물질

3

반응물 2

HCID 8193696-chloro-N-isopropylnicotinamideHCID 226446811-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

생성물 1

HCID 226446375-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

실험 절차

The title compound was prepared from the product of step (ii) (0.36 g) and the product from example 117 step (i) (0.466 g) using the method of example 115 step (ii). Yield 0.112 g

출처 및 근거

ORD 기록
ord-372703aa2407456fb403edf33930f71c
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06812226B2

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