Citric Acid → Formoterol

HRID 2414707

반응식

HRID 2414707 반응식
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C([O-])(=O)CC(CC([O-])=O)(C([O-])=O)O.[Na+].[Na+].[Na+].[Cl-].[Na+].[CH3:32][CH:33]([NH:43][CH2:44][CH:45]([OH:56])[C:46]1[CH:47]=[CH:48][C:49]([OH:55])=[C:50]([NH:52][CH:53]=[O:54])[CH:51]=1)[CH2:34][C:35]1[CH:36]=[CH:37][C:38]([O:41][CH3:42])=[CH:39][CH:40]=1.C(/C(O)=O)=C\C(O)=O.O.O>O>[CH3:32][CH:33]([NH:43][CH2:44][CH:45]([OH:56])[C:46]1[CH:47]=[CH:48][C:49]([OH:55])=[C:50]([NH:52][CH:53]=[O:54])[CH:51]=1)[CH2:34][C:35]1[CH:36]=[CH:37][C:38]([O:41][CH3:42])=[CH:39][CH:40]=1

참가 물질

6

반응물 4

HCID 311Citric AcidHCID 5234Sodium ChlorideHCID 6224Trisodium citrateHCID 11954385HCID 11954385, 화합물

생성물 1

HCID 3410Formoterol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 5 L stainless steel vessel were added 0.68 g citric acid USP, 1.99 g sodium citrate USP, and 17.5 g sodium chloride USP. Purified water USP (2 L) was added to the stainless steel vessel and the contents were mixed with an overhead stirrer at a speed of 240 rpm for 10 minutes. Formoterol fumarate dihydrate (0.17 g for low dosage strength formulation, 0.34 g for high dosage strength formulation) was added and the solution was stirred at 240 rpm for 90 minutes.

후처리

  1. additionthe contents were mixed with an overhead stirrer at a speed of 240 rpm for 10 minutes

출처 및 근거

ORD 기록
ord-dc457e0745ea43b0b61c4929397116fa
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06814953B2

연결된 노트

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