Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → (3-Benzyloxy-4-methoxybenzyl)(5-chloro-2,6-dimethylpyrimidin-4-yl)amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-(Benzyloxy)-4-(chloromethyl)-1-methoxybenzene | HCID 280224 | — |
| 반응물 | 4-Amino-5-chloro-2,6-dimethylpyrimidine | HCID 593843 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | (3-Benzyloxy-4-methoxybenzyl)(5-chloro-2,6-dimethylpyrimidin-4-yl)amine | HCID 22639999 | — |
반응 단계
In analogy to the method described in example A1, 6.11 g (38 mmol) of 4-amino-5-chloro-2,6-dimethylpyrimidine, 10.5 g (40 mmol) of 3-benzyloxy-4-methoxybenzyl chloride and 1.52 g (38 mmol) of sodium hydride (60% suspension in liquid paraffin) are reacted in a total of 225 ml of N-methylpyrrolidone. After chromatography on silica gel (mobile phase: toluene/dioxane=10:1) and crystallization from petroleum ether, the title compound is isolated as a pale beige solid. Yield: 5.2 g (36% of theory). m.p.: 111-117° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06818642B2 |
| 출처 데이터셋 | uspto-grants-2004_11 |
| ORD ID | ord-da5ef040252f4ae794caf6685df07b0d |
| 출처 메모 | uspto-grants-2004_11 |