Trifluoroacetic acid → 1-(6-Phenyl-pyridin-2-yl)-piperazine

HRID 2415168노트

반응식

HRID 2415168 반응식
[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68577637Tert-butyl 4-(6-phenylpyridin-2-yl)piperazine-1-carboxylate

생성물 1

HCID 226401851-(6-Phenyl-pyridin-2-yl)-piperazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 0.7 g (2.06 mmol) of tert.butyl 4-(6-phenyl-pyridin-2-yl)-piperazine-1-carboxylate and 3 ml of trifluoroacetic acid in 30 ml of dichloromethane is stirred for three hours at ambient temperature. The solvent is then distilled off, the residue is combined with water and made basic with sodium hydroxide solution. It is then extracted with dichloromethane and the organic phase is separated off and dried over sodium sulphate.

후처리

  1. distillationThe solvent is then distilled off
  2. extractionIt is then extracted with dichloromethane
  3. customthe organic phase is separated off
  4. dry with materialdried over sodium sulphate

출처 및 근거

ORD 기록
ord-bc06fdb1fa914bbab7af4e3ad94e33e1
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06818644B1

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