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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2415361생성일: 2026년 10월 27일

1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline → 1-Benzo[1,3]dioxol-5-yl-2-[5-(3,4-dimethoxy-phenyl)-pyrimidin-2-yl]-2,3,4,9-tetrahydro-1H-beta-carboline

https://huagongshe.com/reaction/2415361

반응식

참여 물질

역할이름HCID투입량
반응물1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carbolineHCID 201172—
반응물2-Chloro-5-(3,4-dimethoxyphenyl)pyrimidineHCID 3486989—
용매DimethylformamideHCID 6228—
생성물1-Benzo[1,3]dioxol-5-yl-2-[5-(3,4-dimethoxy-phenyl)-pyrimidin-2-yl]-2,3,4,9-tetrahydro-1H-beta-carbolineHCID 11049430—

반응 단계

Following the same procedure as outlined in Example 12, 1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline (3.73 g, 12.8 mmol) (prepared according to the process as disclosed in WO97/43287, Intermediate 7, page 24) and 2-chloro-5-(3,4-dimethoxylphenyl)pyrimidine (1.60 g, 6.4 mmol) in DMF (50 mL, anhydrous) were reacted to yield the product as a white solid.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06818646B2
출처 데이터셋uspto-grants-2004_11
ORD IDord-b0fdac28f2f34dd4a7f0a2ff7e0ba65c
출처 메모uspto-grants-2004_11