Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (E)-4-[3-Oxo-3-[1,2,3,4-tetrahydro-3-(3,4-methylenedioxyphenyl)-9H-pyrrolo-[3,4-b]quinolin-9-one-2-yl]-1-propenyl]benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | (2E)-2-Benzylidenebutanedioic Acid | HCID 820629 | — |
| 반응물 | 3-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]quinolin-9-one | HCID 10892121 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (E)-4-[3-Oxo-3-[1,2,3,4-tetrahydro-3-(3,4-methylenedioxyphenyl)-9H-pyrrolo-[3,4-b]quinolin-9-one-2-yl]-1-propenyl]benzoic acid methyl ester | HCID 12993029 | — |
반응 단계
Following the procedure outlined in Example 20, 1,2,3,4-tetrahydro-3-(3,4-methylenedioxyphenyl)-9H-pyrrolo-[3,4-b]quinolin-9-one (398 mg, 1.30 mmol) (prepared as in Example 5) was reacted with the acid chloride of (E)-carboxymethyl cinnamic acid (301 mg, 1.34 mmol), in the presence of triethylamine (0.54 mL, 3.87 mmol) in a 1:1 mixture of dichloromethane:THF (40 mL) to yield the product as a tan solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06818646B2 |
| 출처 데이터셋 | uspto-grants-2004_11 |
| ORD ID | ord-de622c823478450f99ecfbcff4224c9d |
| 출처 메모 | uspto-grants-2004_11 |