7-Benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline → 2-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol

HRID 2415464노트

반응식

HRID 2415464 반응식
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][C:15]([CH3:19])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[CH3:19][C:15]1[CH:14]=[C:13]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[C:12]2[C:17](=[CH:18][C:9]([OH:8])=[CH:10][CH:11]=2)[N:16]=1

참가 물질

4

반응물 1

HCID 226413107-Benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline

생성물 1

HCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol수율 96.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 13 g of 7-benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline, product of example 1, dissolved in 750 ml of MeOH was treated with 4 g of palladium on charcoal (10%) and then hydrogenated at RT for 1.5 h until HPLC analysis indicated the completion of the reaction. The catalyst was filtered off, washed with water) and the solution was concentrated in vacuo. The solid that precipitated was collected by filtration and dried in a high vacuum to give 8.9 g (96.2%) of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol as an amorphous yellow solid. ISP mass spectrum, m/e: 229.2 (M+1 calculated for C14H16N2O: 229).

후처리

  1. customthe completion of the reaction
  2. filtrationThe catalyst was filtered off
  3. washwashed with water) and the solution
  4. concentrationwas concentrated in vacuo
  5. customThe solid that precipitated
  6. filtrationwas collected by filtration
  7. customdried in a high vacuum

출처 및 근거

ORD 기록
ord-f2f2c1a93a9549eabd0225aceb952929
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06818767B2

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