HCID 178428840, 화합물 → HCID 178428839, 화합물

HRID 2415503노트

반응식

HRID 2415503 반응식
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([OH:20])=[CH:14][C:15]([CH3:19])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[CH3:19][C:15]1[CH:14]=[C:13]([OH:20])[C:12]2[C:17](=[CH:18][C:9]([OH:8])=[CH:10][CH:11]=2)[N:16]=1

참가 물질

4

반응물 1

HCID 178428840HCID 178428840, 화합물

생성물 1

HCID 178428839HCID 178428839, 화합물수율 111.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 3 g (10.5 mmol) of 7-benzyloxy-2-methyl-quinolin-4-ol, product of example 1 c), dissolved in 270 ml of MeOH was treated with 1 g of palladium on charcoal (10%) and then hydrogenated at RT for 1 h until HPLC analysis indicated the completion of the reaction. The catalyst was filtered off, washed with MeOH, and the solution was concentrated in vacuo. The residue was triturated with ether, collected by filtration and dried in a high vacuum to give 2.05 g (98.6%) 2-methyl-quinoline-4,7-diol as an off-white solid. ISP mass spectrum, m/e: 176.2 (M+1 calculated for C10H9NO2: 176).

후처리

  1. customthe completion of the reaction
  2. filtrationThe catalyst was filtered off
  3. washwashed with MeOH
  4. concentrationthe solution was concentrated in vacuo
  5. customThe residue was triturated with ether
  6. filtrationcollected by filtration
  7. customdried in a high vacuum

출처 및 근거

ORD 기록
ord-c1c7d703a2f04f74b0c31d78b23fe05f
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06818767B2

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