Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Alcohol → Benzyl 4-bromo-2-methylbenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Alcohol | HCID 244 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| 용매 | Thionyl Chloride | HCID 24386 | — |
| 생성물 | Benzyl 4-bromo-2-methylbenzoate | HCID 22568915 | 80% |
반응 단계
Using General Esterification Method C; 2-methyl-4-bromo-benzoic acid (2.15 g, 10.0 mmols) was refluxed for 3 h with 10 mL SOCl2. The resulting solution concentrated under reduced pressure and the crude acyl chloride was combined with benzyl alcohol (1.08 g, 10.0 mmols) and pyridine (1.6 mL, 20.0 mmols) to give the title compound (2.4 g, 80%) after work-up and column chromatography (2-5% EtOAc—hexanes) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855512B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-5de0a88c24604da7b67995b4dbd98c81 |
| 출처 메모 | uspto-grants-2005_02 |