Hydrazine → tert-Butyl 4,6-dihydropyrrolo(3,4-c)pyrazole-5(1H)-carboxylate
반응식
[NH2:1]N.C[N:4](/[CH:6]=[C:7]1/[CH2:8][N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:10][C:11]/1=O)C>C(O)C>[NH:1]1[C:11]2[CH2:10][N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:8][C:7]=2[CH:6]=[N:4]1참가 물질
4
실험 절차
A solution of hydrazine (3 mL) and tert-butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate (19.22 g) in ethanol (40 mL) was heated at 85° C. in a sealed tube for 4 h. Solvent was removed under reduced pressure, and the residue was triturated with dichloromethane (160 mL) and ethyl acetate (15 mL). The resulting solid was filtered. The filtrate was concentrated and the resulting solid was triturated again. The combined solids were used in the next step.
후처리
- customSolvent was removed under reduced pressure
- customthe residue was triturated with dichloromethane (160 mL) and ethyl acetate (15 mL)
- filtrationThe resulting solid was filtered
- concentrationThe filtrate was concentrated
- customthe resulting solid was triturated again
출처 및 근거
- ORD 기록
- ord-fd4c7b181d984b04853f1342e9f2316a
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08653059B2
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