Thionyl Chloride → 1,2,3,4-Tetrahydrophthalazine

HRID 2415687노트

반응식

HRID 2415687 반응식
C(OC([N:8]1[N:17](C(OC(C)(C)C)=O)[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.O=S(Cl)Cl>CO>[CH2:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:16][NH:17][NH:8]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 15322838HCID 15322838, 화합물

생성물 1

HCID 831841,2,3,4-Tetrahydrophthalazine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1,4-dihydrophthalazine-2,3-dicarboxylic acid di-tert-butyl ester, 4, (1.0 g, 3 mmol) is dissolved in MeOH (20 mL) and SOCl2 (0.5 mL) added dropwise. After stirring at room temp for 72 hours, the solvent is removed in vacuo to afford 0.6 g of the desired product as white solid.

후처리

  1. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-cbb1ab4d149548338813ca03df9f117c
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06821971B2

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