N-(2-bromo-phenyl)-3-ethoxy-acrylamide → 8-Bromo-1,2-dihydroquinolin-2-one

HRID 2415890

반응식

HRID 2415890 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:15])[CH:10]=[CH:11]OCC>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9](=[O:15])[CH:10]=[CH:11]2

참가 물질

3

반응물 1

HCID 68586854N-(2-bromo-phenyl)-3-ethoxy-acrylamide

생성물 1

HCID 109330948-Bromo-1,2-dihydroquinolin-2-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

6 g (22.21 mmol) of N-(2-bromo-phenyl)-3-ethoxy-acrylamide are added batchwise to 30 ml of concentrated sulphuric acid (exothermic) and stirred for one hour. The reaction mixture is poured onto ice water and the precipitate formed is filtered off. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1).

후처리

  1. additionThe reaction mixture is poured onto ice water
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customThe product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1)

출처 및 근거

ORD 기록
ord-42055ce2719743f388da10fbe354df72
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06821967B2

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