4-Methyl-2-piperazin-1-yl-quinoline → 9-{4-[4-(4-methyl-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide
반응식
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23]Br)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[CH3:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[N:31]=[C:30]([N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[CH:29]=1>>[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][N:41]2[CH2:42][CH2:43][N:38]([C:30]3[CH:29]=[C:28]([CH3:27])[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[N:31]=3)[CH2:39][CH2:40]2)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]참가 물질
3
실험 절차
Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 4-methyl-2-piperazin-1-yl-quinoline.
출처 및 근거
- ORD 기록
- ord-e4f9c87b23aa4cfcb43d278708167530
- 출처 데이터셋
- uspto-grants-2004_11