HCID 22631041, 화합물 → HCID 22630936, 화합물
반응식
[N:1]1([C:6]2[N:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH2:14][OH:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1>CC(C)=O.O=[Mn]=O>[N:1]1([C:6]2[N:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH:14]=[O:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1참가 물질
4
실험 절차
A mixture of the compound from step C (185 mg, 0.92 mmol) and MnO2 (1.60 g, 18.40 mmol) in acetone (15 mL) was heated to reflux for 1 h. The cooled reaction mixture was filtered through Celite and the filtrate was concentrated. Purification by chromatography (SiO2, 2:1 hexane/ethyl acetate) yielded 78 mg (43%) of the title compound. MS 200 (M+H)+.
후처리
- temperaturewas heated
- temperatureto reflux for 1 h
- customThe cooled reaction mixture
- filtrationwas filtered through Celite
- concentrationthe filtrate was concentrated
- customPurification by chromatography (SiO2, 2:1 hexane/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-a4e960cad5f046569cea454ee39f877b
- 출처 데이터셋
- uspto-grants-2004_11
- 특허 번호
- US06825170B2
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