Ammonium Hydroxide → 4-(Aminomethyl)oxan-4-ol

HRID 241651

반응식

HRID 241651 반응식
[O:1]1[C:3]2([CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)[CH2:2]1.[NH4+:9].[OH-]>CO>[NH2:9][CH2:2][C:3]1([OH:1])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 1604391,6-Dioxaspiro[2.5]octane

생성물 1

HCID 436087544-(Aminomethyl)oxan-4-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The methanol solution of 1,6-dioxaspiro[2.5]octane (3.15 g, 27.6 mmol) was added to the 25% ammonia aqueous solution (50.0 mL, 27.6 mmol) at 0° C. The mixture was warmed to room temperature and stirred for 18 h. The reaction mixture was concentrated in vacuo. The crude product was used for next step reaction without purification.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude product was used for next step reaction without purification

출처 및 근거

ORD 기록
ord-fc00036b66ec41eeb5e44cf2df03e5b5
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653063B2

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