참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl propiolate | HCID 13536 | — |
| 반응물 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 반응물 | 3-Aminocrotonitrile | HCID 5324720 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Hydroxy-2-methylnicotinonitrile | HCID 11378516 | — |
반응 단계
A solution of (E)-3-amino-but-2-enenitrile (100 g) and propynoic acid methyl ester in DMF (200 ml) was stirred at 25° C. for 2 h and refluxed for additional 1 h. Dowtherm (100 ml) was added and the temperature was raised to 230° C. DMF and MeOH were distilled off. The reaction mixture was cooled down, EtOAc (200 ml) was added and the resulting crystals were filtered off and washed with EtOAc and ether affording the title compound (44.8 g, FP>250° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08653075B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_02 |
|---|
| ORD ID | ord-61b9afaa144d4e7699a02c1b23f562a5 |
|---|
| 출처 메모 | uspto-grants-2014_02 |
|---|
