Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2,2-Dimethylpropyl 2-methyl-4-bromobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Neopentyl alcohol | HCID 6404 | — |
| 반응물 | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| 용매 | Thionyl Chloride | HCID 24386 | — |
| 생성물 | 2,2-Dimethylpropyl 2-methyl-4-bromobenzoate | HCID 22568939 | 68% |
반응 단계
Using General Esterification Method C; 2-methyl-4-bromo-benzoic acid (1.82 g, 8.47 mmols) was refluxed for 3 h with 10 mL SOCl2. The resulting solution was concentrated under reduced pressure and the crude acyl chloride combined with 2,2-dimethylpropanol (0.75 g, 8.47 mmols) and pyridine (1.4 mL, 16.9 mmols) to give the title compound (1.64 g, 68%) after work-up and column chromatography (2-5% EtOAc—hexanes) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855512B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-63449081144e47959fac4c07d18503df |
| 출처 메모 | uspto-grants-2005_02 |