Acetonitrile → HCID 15688742, 화합물
반응식
I[Si](C)(C)C.C(#N)C.[Cl:9][CH2:10][CH2:11][CH2:12][C:13]([CH3:20])([CH3:19])[C:14]([O:16]CC)=[O:15]>O>[Cl:9][CH2:10][CH2:11][CH2:12][C:13]([CH3:20])([CH3:19])[C:14]([OH:16])=[O:15]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
Iodotrimethylsilane (3.00 g, 15 mmols) was added to an acetonitrile solution (5 ml) of ethyl 5-chloro-2,2-dimethylpentanoate (963 mg, 5 mmols) at room temperature, and heated at 80° C. for 24 hours with stirring. The reaction mixture was poured into water with ice, and extracted with ether. The organic layer was washed with water, and dried with anhydrous magnesium sulfate, and the solvent was evaporated to obtain 0.9 g of 5-chloro-2,2-dimethylpentanoic acid as a brown oil.
후처리
- extractionextracted with ether
- washThe organic layer was washed with water
- dry with materialdried with anhydrous magnesium sulfate
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-68ed247a54704339a08fedca0ee3a31a
- 출처 데이터셋
- uspto-grants-2004_11
- 특허 번호
- US06825223B2
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