Isonicotinic Acid → N-(2-Methoxyphenyl)isonicotinamide

반응식

[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.[C:10]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)(O)=[O:11]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[O:11]

참가 물질

반응물 2

HCID 5922Isonicotinic Acid

HCID 70002-Methoxyaniline

생성물 1

HCID 571556N-(2-Methoxyphenyl)isonicotinamide수율 97.3%

실험 절차

Using o-anisidine (2.34 g, 19.0 mmol) and 4-carboxypyridine (2.29 g, 19.0 mmol), the procedure of Reference Example 11 was repeated to obtain 4.22 g (97.2%) of the title compound in the form of colorless powder.

출처 및 근거

ORD 기록: ord-a73df83aa26e46b6a84924990ae0f10f
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05728835

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