p-Chlorophenacyl bromide → 1-(4-Chlorophenyl)-2-hydroxyethan-1-one

HRID 241738

반응식

HRID 241738 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[K+]>CO>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 68303p-Chlorophenacyl bromideHCID 2735122Potassium Formate

생성물 1

HCID 5870851-(4-Chlorophenyl)-2-hydroxyethan-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.

후처리

  1. temperatureat reflux for 3 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. customThe solid formed
  5. filtrationis filtered off
  6. washwashed with cold MeOH
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-6f0e5a2260e14700985cfcc1f1b5068d
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653073B2

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