HCID 69818250, 화합물 → HCID 69818475, 화합물

HRID 2417422노트

반응식

HRID 2417422 반응식
C([N:8]([C@H:20]([CH2:34][OH:35])[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][CH2:32][CH3:33])=[O:30])=[CH:24][CH:23]=1)[CH2:9][C@H:10]([OH:19])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[CH2:32]([NH:31][C:29]([NH:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][C@H:20]([NH:8][CH2:9][C@H:10]([OH:19])[CH2:11][O:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:34][OH:35])=[CH:27][CH:26]=1)=[O:30])[CH3:33]

참가 물질

4

반응물 1

HCID 69818250HCID 69818250, 화합물

생성물 1

HCID 69818475HCID 69818475, 화합물수율 64.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of N-[4-[(2S)-2-[N-benzyl-N-[(2S)-2-hydroxy-3-phenoxypropyl]amino]-3-hydroxypropyl]phenyl]-N′-ethylurea (73 mg) in methanol (1.5 ml) was hydrogenated (1 atm) over 10% palladium on carbon (11 mg) at room temperature for 12 hours. After the catalyst was filtered off, the filtrate was concentrated and the residue was purified by column chromatography (silica gel, chloroform/methanol) followed by recrystallization from ehtanol/hexane to give N-ethyl-N′-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]-propyl]phenyl]urea (38 mg) as a white powder.

후처리

  1. customat room temperature
  2. customfor 12 hours
  3. filtrationAfter the catalyst was filtered off
  4. concentrationthe filtrate was concentrated
  5. customthe residue was purified by column chromatography (silica gel, chloroform/methanol)
  6. customfollowed by recrystallization from ehtanol/hexane

출처 및 근거

ORD 기록
ord-f1aac32679234d3f9e962dbd6cba462a
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06826033B2

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