Sodium Bicarbonate → Ethyl (5-methyl-2-nitrobenzyl)aminoacetate

HRID 2417501노트

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HRID 2417501 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7]Cl.Cl.[CH2:14]([O:16][C:17](=[O:20])[CH2:18][NH2:19])[CH3:15].C(=O)([O-])O.[Na+]>C(O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7][NH:19][CH2:18][C:17]([O:16][CH2:14][CH3:15])=[O:20]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 2723640Glycine ethyl ester, hydrochlorideHCID 2724031alpha-Chloro-5-methyl-2-nitrotoluene

생성물 1

HCID 86217985Ethyl (5-methyl-2-nitrobenzyl)aminoacetate

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

5.0 g (27 mmol) of 5-methyl-2-nitrobenzyl chloride was dissolved in 100 ml of ethanol. 7.5 g (54 mmol) of glycine ethyl ester hydrochloride and 6.8 g (81 mmol) of sodium hydrogencarbonate were added to the obtained solution, and they were stirred at 70° C. for 6 hours. The solvent was evaporated. After the extraction with ethyl acetate, the extract was washed with 1 N hydrochloric acid. The obtained aqueous layer was made basic with 1 N sodium hydroxide. After the extraction with ethyl acetate, the obtained organic layer was washed with saturated aqueous sodium chloride solution and then dried. The solvent was evaporated to obtain the title compound.

후처리

  1. customThe solvent was evaporated
  2. extractionAfter the extraction with ethyl acetate
  3. washthe extract was washed with 1 N hydrochloric acid
  4. extractionAfter the extraction with ethyl acetate
  5. washthe obtained organic layer was washed with saturated aqueous sodium chloride solution
  6. customdried
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-cca4db19afb44e3eb28baac5f8cab456
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825191B2

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