Ammonium Hydroxide → HCID 13338422, 화합물

HRID 2417663노트

반응식

HRID 2417663 반응식
Cl[C:2]1[C:3]2[N:11]([CH3:12])[N:10]=[C:9]([CH3:13])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[NH2:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17].[OH-].[NH4+]>C1(C)C=CC=CC=1>[CH3:12][N:11]1[C:3]2[C:2]([NH:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17])=[N:7][C:6]([CH3:8])=[N:5][C:4]=2[C:9]([CH3:13])=[N:10]1

참가 물질

5

반응물 3

HCID 14923Ammonium HydroxideHCID 221292-Amino-1-butanolHCID 133384077-Chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine

생성물 1

HCID 13338422HCID 13338422, 화합물수율 30.1%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 8 g (0.04 mol) of 7-chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine (Ex. 3) and 9 g (0.1 mol) of 2-amino-1-butanol in 75 ml of toluene is heated on the steam bath four hours. The warm solution is shaken with 100 ml of 4N ammonium hydroxide. The aqueous extract is concentrated in vacuo to give 3 g of 2-[1,3,5-trimethyl-1-H-pyrazolo[4,3-d]pyrimidin-7-yl]amino-1-butanol, mp 165°-168° C. Another 2.2 g of product is obtained by concentrating the toluene solution.

후처리

  1. temperatureis heated on the steam bath four hours
  2. extractionThe aqueous extract
  3. concentrationis concentrated in vacuo

출처 및 근거

ORD 기록
ord-57062a4cfad54e8f8747450cc0ca1c5c
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04469868

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