Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methane → Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methane | HCID 297 | — |
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate | HCID 104609 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxylate | HCID 104610 | — |
반응 단계
A mixture of 24.7 g of 1-carbethoxy-4-(2-amino-4-chloroanilino)-piperidine and 7.2 g of urea was heated to 160°-180° C. for 3.5 hours. The melt was taken up in 250 ml of toluene and heated, while stirring, until everything had dissolved. The solution was clarified with active charcoal, filtered and concentrated to 50 ml. The product was precipitated with diisopropyl ether. Melting point: 160° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04470989 |
| 출처 데이터셋 | uspto-grants-1984_09 |
| ORD ID | ord-ce47b2e418934eda94a0f219f6f3ac23 |
| 출처 메모 | uspto-grants-1984_09 |